About 25 results found for searched term "Progesterone Receptor" (0.18 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3256 | Eplerenone | Others |
| Epoxymexrenone | ||
| Eplerenone (Epoxymexrenone) is a selective, competitive and oral aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen, and glucocorticoid receptors. Eplerenone may be used in studies of hypertension and heart failure following myocardial infarction. | ||
| M3510 | Mifepristone | Progesterone Receptor |
| RU486; C-1073; RU 38486 | ||
| Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. | ||
| M5544 | Cyproterone Acetate | Androgen Receptor |
| Cyproterone acetate is an androgen receptor (AR) antagonist with IC50 of 7.1 nM, as well as a weak progesterone receptor agonist with weak pro-gestational and glucocorticoid activity. | ||
| M5635 | Etonogestrel | Estrogen Receptor |
| Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel | ||
| Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. | ||
| M5698 | Hydroxyprogesterone caproate | Estrogen Receptor |
| 17α-Hydroxyprogesterone hexanoate, 17α-Hydroxyprogesterone caproate | ||
| Hydroxyprogesterone Caproate is a synthetic progesterone receptor (PR) agonist that binds and activates the nuclear progesterone receptor in the reproductive system and may be used in studies related to genitourinary disorders. | ||
| M5764 | Medroxyprogesterone acetate | Androgen Receptor |
| NSC-26386 | ||
| Medroxyprogesterone acetate (MPA) is a synthetic progestin and act as a potent progesterone receptor agonist, used to treat abnormal menstruation or irregular vaginal bleeding. | ||
| M5902 | Progesterone | Animal Modeling |
| Pregn-4-ene-3,20-dione | ||
| Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. It can be used to construct a model of melasma as well as a model of fibrocystic hyperplasia of the breast. | ||
| M6043 | Ulipristal acetate | Progesterone Receptor |
| CDB-2914 | ||
| Ulipristal acetate(CDB2914) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma. | ||
| M8119 | PF-02413873 | Progesterone Receptor |
| PF-02413873 is a potent, selective and fully competitive non-steroidal progesterone receptor (PR) antagonist that blocks progesterone binding and PR nuclear translocation. | ||
| M8236 | Nomegestrol acetate | Others |
| Nomegestrol acetate (NOMAc) is a potent, highly selective progestogen, a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors. | ||
| M8390 | Nestorone | Progesterone Receptor |
| Elcometrine; Nestorone; ST-1435 | ||
| Nestorone is a potent progesterone receptor agonist with no androgenic, estrogenic, or glucocorticoid-like activities. | ||
| M9125 | Z-Guggulsterone | Farnesoid X Receptor |
| Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). | ||
| M9957 | Finerenone | Mineralocorticoid Receptor |
| BAY94-8862 | ||
| Finerenone (BAY 94-8862) is a third generation selective, oral active, non-steroidal halocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone showed good selectivity (>500-fold) compared to glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (AR). Finerenone has potential applications in the study of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease. | ||
| M14337 | 11beta-Hydroxyprogesterone | Metabolite/Endogenous Metabolite |
| 11β-Hydroxyprogesterone | ||
| 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. | ||
| M14796 | Medroxyprogesterone | Progesterone Receptor |
| 17α-Hydroxy-6α-methylprogesterone; U8840 | ||
| Medroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist. | ||
| M14797 | Tanaproget | Progesterone Receptor |
| NSP-989 | ||
| Tanaproget (NSP-989) is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins. | ||
| M20905 | Lynestrenol | Estrogen Receptor |
| Ethinylestrenol | ||
| Lynestrenol is a synthetic progestational hormone, an agonist of the progesterone receptor and has weak androgenic and estrogenic activity. | ||
| M21160 | ARD-61 | PROTAC |
| ARD-61 is a potent and specific PROTAC androgen receptor (AR) depressant. ARD-61 effectively and efficiently induces AR and progesterone receptor (PR) degradation in AR+ cancer cell lines. ARD-61 induces apoptosis and also effectively inhibits tumor growth in a mouse MDA-MB-453 xenograft model. | ||
| M29084 | Asoprisnil | Progesterone Receptor |
| J867 | ||
| Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. | ||
| M29239 | OP-3633 | GCR |
| OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism. | ||
| M29590 | AL-438 | GCR |
| AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity. | ||
| M30029 | Cridanimod | Progesterone Receptor |
| Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer. | ||
| M30085 | Allylestrenol | Progesterone Receptor |
| Allylestrenol is an anabolic steroid with progesterone activity and potential physiologic function as a progesterone receptor agonist that can be used in studies related to preterm labor. | ||
| M30099 | (rac)-AG-205 | NF-κB |
| (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway. | ||
| M30327 | Nomegestrol | Progesterone Receptor |
| Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity. | ||
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